Moderate to severe pain syndrome of different genesis (including malignant tumors, acute myocardial infarction, neuralgia, trauma). Painful diagnostic or therapeutic procedures.
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Hypersensitivity, intoxication by alcohol, hypnotics, narcotic analgesics and other psychoactive drugs, pregnancy, lactation (in case of long-term use), children (under 1 year old – for parenteral administration; under 14 years old – for oral administration), taking MAO inhibitors.
Opioid addiction, impaired consciousness of various genesis, intracranial hypertension, head injuries, epileptic syndrome (cerebral genesis), conditions accompanied by respiratory depression or pronounced CNS depression.
Pregnancy and lactation:
Adequate and well-controlled studies in humans have not been performed. In animals it caused embryo- and fetotoxic, but not teratogenic effects. Do not use! Penetrates into breast milk at low doses. Do not use!
FDA recommendations – Category C.
Directions for use and dosage:
Adults and children over 14 years of age, single dose when administered orally is 50 mg, rectally 100 mg, intravenously slowly or intramuscularly 50-100 mg. If parenteral administration is not effective enough, an oral dose of 50 mg is possible after 20-30 minutes.
The dosage for children aged 1 to 14 years is established at the rate of 1 to 2 mg/kg.
The duration of treatment is determined individually.
Maximum dose: for adults and children over 14 years old regardless of the method of administration – 400 mg per day.
Synthetic opioid analgesic, lower affinity for opioid receptors-10 times compared to codeine and 6,000 times compared to morphine. However, the active metabolite is 2-4 times more active than tramadol. Severity of analgesic effect: 5-10 times weaker than morphine.
Tramadol is effective for back pain; however, the appropriateness of its use for this condition requires further research.