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Is Xanax Right For You?

Indications for active substances of Xanax®

Anxiety, neurosis accompanied by anxiety, danger, restlessness, tension, sleep disturbance, irritability, as well as somatic disorders; mixed anxiety-depressive states; neurotic reactive-depressive states accompanied by depressed mood, loss of interest in others, restlessness, sleep loss, decreased appetite, somatic disorders; anxiety and neurotic depression developed against somatic diseases; panic disorders with or without symptoms.

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Dosage

Minimum effective doses are recommended. The dose is adjusted during treatment depending on the effect achieved and tolerability. If it is necessary to increase the dose, it should be increased gradually, first in the evening and then in the daytime.

The initial dose is 250-500 mcg 3 times/day, with a gradual increase to 4.5 mg/day if necessary.

For elderly or weakened patients, the initial dose is 250 mcg 2-3 times/day, maintenance doses are 500-750 mcg/day, and the dose can be increased if necessary, taking into account tolerance.

Alprazolam should be withdrawn or reduced gradually, reducing the daily dose by no more than 500 micrograms every 3 days; even slower withdrawal may sometimes be necessary.

Contraindications to use


Coma, shock, myasthenia gravis, closed-angle glaucoma (acute onset or predisposition), acute alcohol poisoning (with impairment of vital functions), opioid analgesics, sleeping pills and psychotropic agents, chronic obstructive respiratory diseases with initial manifestations of respiratory failure, acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially I trimester), lactation, childhood and adolescence under 18 years of age, hypersensitivity to benzodiazepines.

What Is Tramadol?

Indications:


Moderate to severe pain syndrome of different genesis (including malignant tumors, acute myocardial infarction, neuralgia, trauma). Painful diagnostic or therapeutic procedures.

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Contraindications
Hypersensitivity, intoxication by alcohol, hypnotics, narcotic analgesics and other psychoactive drugs, pregnancy, lactation (in case of long-term use), children (under 1 year old – for parenteral administration; under 14 years old – for oral administration), taking MAO inhibitors.

Caution:
Opioid addiction, impaired consciousness of various genesis, intracranial hypertension, head injuries, epileptic syndrome (cerebral genesis), conditions accompanied by respiratory depression or pronounced CNS depression.

Pregnancy and lactation:
Adequate and well-controlled studies in humans have not been performed. In animals it caused embryo- and fetotoxic, but not teratogenic effects. Do not use! Penetrates into breast milk at low doses. Do not use!

FDA recommendations – Category C.

Directions for use and dosage:
Adults and children over 14 years of age, single dose when administered orally is 50 mg, rectally 100 mg, intravenously slowly or intramuscularly 50-100 mg. If parenteral administration is not effective enough, an oral dose of 50 mg is possible after 20-30 minutes.

The dosage for children aged 1 to 14 years is established at the rate of 1 to 2 mg/kg.

The duration of treatment is determined individually.

Maximum dose: for adults and children over 14 years old regardless of the method of administration – 400 mg per day.

Specific Notes:

Synthetic opioid analgesic, lower affinity for opioid receptors-10 times compared to codeine and 6,000 times compared to morphine. However, the active metabolite is 2-4 times more active than tramadol. Severity of analgesic effect: 5-10 times weaker than morphine.

Tramadol is effective for back pain; however, the appropriateness of its use for this condition requires further research.